Indirect coombs test (maternal serum mixed with Rh-positive RBC's) direct coombs tests whether baby's RBC's agglutinate in the presence of anti-Rh IgG What test should be performed to determine if a mother has anti-Rh IgG? What effect will isoproterenol have on SVR and heart rate?īeta-adrenergic agonist HR would increase and SVR would decrease due to beta 2 dilation of arterioles HR will increase alpha activity will be blocked by phentolamine so there will be neither an increase or a decrease in SVR (unlike epinephrine which has beta 2 activity and would decrease SVR) What effect will norepinephrine have on SVR and heart rate in the presence of phentolamine? HR will increase Alpha activity will be blocked by phentolamine, but beta 2 will dilate arterioles decreasing SVR (this is in contrast to the increase in SVR seen w/out phentolamine) What effect will epinephrine have on SVR and heart rate in the presence of phentolamine? Phentolamine has what effect on systemic vascular resistance and heart rate?Īlpha-adrenergic receptor it will decrease SVR, HR will increase, however, due to baroreceptor response to drop in blood pressure Biopsy reveals atrophied villi in jejunum. Patient presents with 3 month weight loss, diarrhea, and flatulence. What's the difference between 5HT1A agonists and 5HT1D agonists?ĥHT1A agonist is the mechanism of the anxiolytic buspirone 5HT1D agonist is the mechanism of the migraine drug sumatriptan What's the difference in 5HT2 and 5HT3 blocking drugs?ĥHT2 blockade is the mechanism of atypical antipsychotics (clozapine) 5HT3 blockade is the mechanism of the antiemetic ondansetron Heart disease and RA: AA amyloid Medullary carcinoma: AE Myeloma and b-cell lymphoma: AL What types of amyloid are associated with heart disease and rheumatoid arthritis, medullary carcinoma, myelomas and B-cell lymphomas? Midshaft: brachial artery Surgical neck: posterior circumflex artery (axillary nerve might also be injured here) What arteries would likely be lacerated in a midshaft versus a surgical neck fracture of the humerus? Severe combined immunodeficiency (SCID) chronic diarrhea, ear infections, pneumocystis jirovecii pneumonia, and oral candidiasis are common (note: X linked is the IL-2 form) Rheumatoid arthritis and DM type 1 (along with DR3)Īdenosine deaminase, defective IL-2 receptor, and nonsense RAG mutations are all causes of this disorder. HLA DR4 is associated with what disorders?

HLA-DR2 and DR3 are associated with what disorder? Psoriatic arthritis, ankylosing spondylitis, inflammatory bowel disease, and Reiter syndrome (arthritis, urethritis, conjunctivitis)

HLA-B27 is associated with what disorders? Gout needle-like crystals that are strongly negatively birefringent Leukemia, Lesch-Nyhan syndrome, chronic renal disease, and alcohol intake can all cause what disorder? As a result, patients with Wiskott-Aldrich Syndrome develop recurrent infections (immunodeficiency), eczema, and thrombocytopenia.General 2 Q bank: Randomly Generated 2 Question This mutation in WAS results in problems with cytoskeleton reorganization in leukocytes and platelets. Wiskott-Aldrich Syndrome is caused by a mutation in the WAS gene, which is an abbreviation for Wiskott-Aldrich Syndrome gene. Summary Wiskott Aldrich Syndrome is an X-linked recessive immunodeficiency.

What mutations in scid usmle